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Generic Name: Paroxetine Tablets (par-OX-e-teen)
Brand Name: Paxil
Antidepressants may increase the risk of suicidal thoughts
or actions in children, teenagers, and young adults. However,
depression and certain other mental problems may also increase
the risk of suicide. Talk with the patient's doctor to be
sure that the benefits of using Paxil outweigh the risks.
Family and caregivers must closely watch patients who take
Paxil. It is important to keep in close contact with the patient's
doctor. Tell the doctor right away if the patient has symptoms
like worsened depression, suicidal thoughts, or changes in
behavior. Discuss any questions with the patient's doctor.
Paxil is used for:
Treating depression or obsessive-compulsive disorder (OCD).
It may be used to treat panic disorder or posttraumatic stress
disorder (PTSD). It may also be used to treat generalized
anxiety disorder or social anxiety disorder. It may also be
used for other conditions as determined by your doctor.
Paxil is a selective serotonin reuptake inhibitor (SSRI).
It works by restoring the balance of serotonin, a natural
substance in the brain, which helps to improve certain mood
problems.
Do NOT use Paxil if:
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you are allergic to any ingredient in Paxil |
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you are taking or have taken a monoamine oxidase inhibitor
(MAOI) (eg, phenelzine), selegiline, or St. John's wort
within the last 14 days |
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you are taking a fenfluramine derivative (eg, dexfenfluramine),
nefazodone, pimozide, a serotonin norepinephrine reuptake
inhibitor (SNRI) (eg, venlafaxine), sibutramine, thioridazine,
or tryptophan |
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Contact
your doctor or health care provider right away if any
of these apply to you. |
Before using Paxil:
Some medical conditions may interact with Paxil . Tell your
doctor or pharmacist if you have any medical conditions, especially
if any of the following apply to you:
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if you are pregnant, planning to become
pregnant, or are breast-feeding |
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if you are taking any prescription or nonprescription
medicine, herbal preparation, or dietary supplement |
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if you have allergies to medicines, foods, or other
substances |
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if you or a family member has a history of bipolar disorder
(manic-depression), other mental or mood problems, suicidal
thoughts or attempts, or alcohol or substance abuse |
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if you have a history of seizures, heart problems, liver
problems, severe kidney problems, stomach or bowel bleeding,
narrow-angle glaucoma, diabetes, or metabolism problems |
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if you are dehydrated, have low blood sodium levels,
or drink alcohol |
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if you will be having electroconvulsive therapy (ECT)
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Some MEDICINES
MAY INTERACT with Paxil. Tell your health care provider
if you are taking any other medicines, especially any
of the following: |
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Anorexiants (eg, phentermine), cimetidine, fenfluramine
derivatives (eg, dexfenfluramine), linezolid, lithium,
MAOIs (eg, phenelzine), metoclopramide, nefazodone, selegiline,
serotonin 5-HT1 receptor agonists (eg, sumatriptan), SNRIs
(eg, venlafaxine), sibutramine, St. John's wort, tramadol,
trazodone, or tryptophan because severe side effects,
such as a reaction that may include fever, rigid muscles,
blood pressure changes, mental changes, confusion, irritability,
agitation, delirium and coma may occur |
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Anticoagulants (eg, warfarin), aspirin, or nonsteroidal
anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because
the risk of bleeding, including stomach bleeding, may
be increased |
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Diuretics (eg, furosemide, hydrochlorothiazide) because
the risk of blood sodium levels may be increased |
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Antiarrhythmics (eg, flecainide, propafenone, quinidine),
H1 antagonists (eg, astemizole, terfenadine), or phenothiazines
(eg, chlorpromazine, thioridazine) because severe heart
problems, including irregular heartbeat, may occur |
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Cyproheptadine, HIV protease inhibitors (eg, ritonavir),
phenobarbital or phenytoin because they may decrease Paxil
's effectiveness |
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Aripiprazole, atomoxetine, clozapine, fluoxetine, pimozide,
procyclidine, risperidone, theophylline, or tricyclic
antidepressants (eg, amitriptyline) because the risk of
their side effects may be increased by Paxil |
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Digoxin because its effectiveness may be decreased by
Paxil |
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This may
not be a complete list of all interactions that may
occur. Ask your health care provider if Paxil may interact
with other medicines that you take. Check with your
health care provider before you start, stop, or change
the dose of any medicine. |
How to use Paxil:
Use Paxil as directed by your doctor. Check the label on the
medicine for exact dosing instructions.
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Paxil comes with an extra patient information
sheet called a Medication Guide. Read it carefully. Read
it again each time you get Paxil refilled. |
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Take Paxil by mouth with or without food. |
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Swallow Paxil whole. Do not break, crush, or chew before
swallowing. |
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Taking Paxil at the same time each day will help you
remember to take it. |
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Continue to take Paxil even if you feel well. Do not
miss any doses. |
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Do not suddenly stop taking Paxil without checking with
your doctor. Side effects may occur. They may include
mental or mood changes, numbness or tingling of the skin,
dizziness, confusion, headache, trouble sleeping, or unusual
tiredness. You will be closely monitored when you start
Paxil and whenever a change in dose is made. |
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If you miss a dose of Paxil, take it as soon as possible.
If it almost time for your next dose, skip the missed
dose. Go back to your regular dosing schedule. Do not
take 2 doses at once. |
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Ask your
health care provider any questions you may have about
how to use Paxil. |
Important safety information:
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Paxil may cause drowsiness, dizziness, or
blurred vision. These effects may be worse if you take
it with alcohol or certain medicines. Use Paxil with caution.
Do not drive or perform other possibly unsafe tasks until
you know how you react to it. |
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Do not drink alcohol while you are using Paxil. |
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Check with your doctor before you use medicines that
may cause drowsiness (eg, sleep aids, muscle relaxers)
while you are using Paxil ; it may add to their effects.
Ask your pharmacist if you have questions about which
medicines may cause drowsiness. |
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Several weeks may pass before your symptoms improve.
Do NOT take more than the recommended dose, change your
dose, or use Paxil for longer than prescribed without
checking with your doctor. |
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Children, teenagers, and young adults who take Paxil
may be at increased risk for suicidal thoughts or actions.
Watch all patients who take Paxil closely. Contact the
doctor at once if new, worsened, or sudden symptoms such
as depressed mood; anxious, restless, or irritable behavior;
panic attacks; or any unusual change in mood or behavior
occur. Contact the doctor right away if any signs of suicidal
thoughts or actions occur. |
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If your doctor tells you to stop taking Paxil , you
will need to wait for several weeks before beginning to
take certain other medicines (eg, MAOIs, nefazodone).
Ask your doctor when you should start to take your new
medicines after you have stopped taking Paxil. |
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Paxil may rarely cause a prolonged, painful erection.
This could happen even when you are not having sex. If
this is not treated right away, it could lead to permanent
sexual problems such as impotence. Contact your doctor
right away if this happens. |
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Serotonin syndrome is a possibly fatal syndrome that
can be caused by Paxil. Your risk may be greater if you
take Paxil with certain other medicines (eg, "triptans,"
MAOIs). Symptoms may include agitation; confusion; hallucinations;
coma; fever; fast or irregular heartbeat; tremor; excessive
sweating; and nausea, vomiting, or diarrhea. Contact your
doctor at once if you have any of these symptoms. |
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Caution is advised when using Paxil in the ELDERLY;
they may be more sensitive to its effects, especially
low blood sodium levels. |
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Caution is advised when using Paxil in CHILDREN; they
may be more sensitive to its effects, especially increased
risk of suicidal thoughts and actions. |
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Paxil should be used with extreme caution in CHILDREN;
safety and effectiveness in these children have not been
confirmed. |
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Paxil may cause weight changes. CHILDREN and teenagers
may need regular weight and growth checks while they take
Paxil. |
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PREGNANCY and BREAST-FEEDING: Paxil may cause harm to
the fetus. If you become pregnant, contact your doctor.
You will need to discuss the benefits and risks of using
Paxil while you are pregnant. Paxil is found in breast
milk. If you are or will be breast-feeding while you use
Paxil , check with your doctor. Discuss any possible risks
to your baby. |
Possible side effects of Paxil:
All medicines may cause side effects, but many people have
no, or minor, side effects. Check with your doctor if any
of these most COMMON side effects persist or become bothersome:
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Anxiety; blurred vision; constipation; decreased
sexual desire or ability; diarrhea; dizziness; drowsiness;
dry mouth; gas; increased sweating; increased urination;
loss of appetite; nausea; nervousness; stomach upset;
trouble concentrating; trouble sleeping; unusual skin
sensations; weakness; yawning. |
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Seek medical
attention right away if any of these SEVERE side effects
occur: |
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Severe allergic reactions (rash; hives; itching; difficulty
breathing; tightness in the chest; swelling of the mouth,
face, lips, or tongue); bizarre behavior; black or bloody
stools; chest pain; exaggerated reflexes; fast or irregular
heartbeat; fever, chills, or sore throat; hallucinations;
loss of coordination; new or worsening agitation, panic
attacks, aggressiveness, impulsiveness, irritability,
hostility, exaggerated feeling of well-being, restlessness,
or inability to sit still; persistent or severe ringing
in the ears; persistent, painful erection; red, swollen,
blistered, or peeling skin; seizures; severe or persistent
anxiety or trouble sleeping; significant weight loss;
stomach pain; suicidal thoughts or attempts; tremor; unusual
bruising or bleeding; unusual or severe mental or mood
changes; vision changes; worsening of depression. |
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